| Application: |
Applications for Fluorescent Dopamine Ligand-Neurotransmitter (DnsylD-1)
DnsylD-1 has the following applicability due to the small molecular size of the dansyl fluorescent label, a long spacer arm between the dopamine structure and the fluorescent tag, stability in aqueous solution and low autofluorescence of the surrounding cellular or tissue medium.
• Histochemical imaging and quantitation of dopamine receptor expression in vivo and vitro.
• Pharmacological applications as a substitute for radioactive ligand.
• Dopamine metabolism and turnover analysis.
• Dopamine uptake analysis.
• Dopaminergic neuron detection.
• Analysis of disease conditions associated with altered dopamine synthesis, dopamine receptor expression or dopamine uptake: human disease research applicability in the following: a) Parkinson's disease. b) Psychological disorder, including ADHD, schizophrenia and substance abuse. c) Physiological regulation of cardiovascular, renal and immune function.
|
