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Sacubitril Impurity E
Synonyms: Desethyl Sacubitril;[S-(R,S)]-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-Biphenyl]-4-pentanoic Acid; (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic Acid; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic Acid; Sacubitrilat; LBQ 657
Cat. No.: S00310	CAS No.: 149709-44-4
MDL.:	Formula: C22H25NO5
F.W.383.44	Purity: 99％
Storage: Refrigerator

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Catalog Number：	S00310		CAS No.:	149709-44-4
MDL:			Formula:	C22H25NO5
F.W.:	383.44		Purity:	99％
Package:			Unit:	mg
Appearance:	White Solid		M.P.:	166-168°C
B.P.:			Density:
Optical Rotation:			Refractive Index:
Solubility:	DMSO (Slightly), Methanol (Slightly)		Stability:
Storage:	Refrigerator		Category:	Reference Standard
Reference:	McMurray, J., et al.: N. Eng. J. Med., 371 (2014);
Application:	Desethyl Sacubitril is an impurity in the synthesis of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Category:	Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals

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