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Amonafide Intermediate D

Synonyms: 1H,3H-Naphtho[1,8-cd]pyran-1,3-dione;1,8-Naphthoic Anhydride; 1,8-Naphthalenedicarboxylic Acid Anhydride; 1,8-Naphthalenedicarboxylic Anhydride; 1,8-Naphthalic Acid Anhydride; 1,8-Naphthalic Anhydride; 1,8-Naphthanoic Anhydride; NSC 5747; Protect; Protect (agrochemical)
Cat. No.: A44513 CAS No.: 81-84-5
MDL.: Formula: C12H6O3
F.W.198.17 Purity: 99%
Storage: Room Temperature, under inert atmosphere
 
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Catalog Number: A44513   CAS No.: 81-84-5
MDL: Formula: C12H6O3
F.W.: 198.17 Purity: 99%
Package: Unit:
Appearance: Pale Yellow Solid M.P.: 273-275°C
B.P.: Density:
Optical Rotation: Refractive Index:
Solubility: Chloroform (Slightly, Heated), DMSO Stability:
Storage: Room Temperature, under inert atmosphere Category: Reference Standard
Reference: Verma, M. et al.: Eur, J, Med. Chem., 68 (2013); Quintana-E,. et al.: Bioorg, Med. Chem., 21, 6484 (2013);
Application: 1,8-Naphthoic Anhydride is used in the synthesis of napthalimide analogues as anticancer agents.;1H,3H-Naphtho[1,8-cd]pyran-1,3-dione is used in the synthesis of Amonafide, which is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment.
Category: Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals