Ziprasidone Impurity A |
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Synonyms: 3-(1-Piperazinyl)-1,2-benzisothiazole;3-(Piperazin-1-yl)benzoisothiazole; N-(3-Benzisothiazolyl)piperazine; 1-(1,2-Benzisothiazol-3-yl)piperazine; Ziprasidone EP Impurity A; | |
Cat. No.: Z74003 | CAS No.: 87691-87-0 |
MDL.: | Formula: C11H13N3S |
F.W.219.31 | Purity: 99% |
Storage: Refrigerator | |
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Catalog Number: | Z74003 | CAS No.: | 87691-87-0 | |
MDL: | Formula: | C11H13N3S | ||
F.W.: | 219.31 | Purity: | 99% | |
Package: | Unit: | |||
Appearance: | Pale Yellow to Yellow Solid | M.P.: | 90 - 92°C | |
B.P.: | Density: | |||
Optical Rotation: | Refractive Index: | |||
Solubility: | DMSO (Slightly), Methanol (Slightly) | Stability: | ||
Storage: | Refrigerator | Category: | Reference Standard | |
Reference: | Prakash, C., et al.: Brit. J. Clin. Pharmacol., 49, 35S (2000); Orjales, A., et al.: J. Med. Chem., 46, 5512 (2003); Graham, J., et al.: Bioorg. Med. Chem. Lett., 18, 489 (2008); Bench, C.J., et al.: Psychopharmacology, 112, 308 (1993), Goldstein, J.M.: Exp. Opin. Invest. Drugs, 4, 291 (1995) | |||
Application: | 3-(1-Piperazinyl)-1,2-benzisothiazole (Ziprasidone EP Impurity A) is a reagent used to synthesize Ziprasidone (Z485000, HCl salt, monohydrate), a combined serotonin (5HT2) and dopamine (D2) receptor antagonist. | |||
Category: | Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |