| Catalog Number： |
D01010 |
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CAS No.: |
1423119-98-5;Unlabelled: 1195765-45-7 |
| MDL: |
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Formula: |
C23H11F3N5O2S2D9 |
| F.W.: |
528.63 |
|
Purity: |
99％ |
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Unit: |
mg |
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Category: |
Reference Standard |
| Reference: |
Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013) |
| Application: |
Dabrafenib-d9 is the isotope labelled analog of Dabrafenib (D101000); an inhibitor of mutated BRAF kinase. Dabrafenib also has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma. |
| Category: |
Amines, Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |
