| Catalog Number： |
D01004 |
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CAS No.: |
60230-36-6 |
| MDL: |
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Formula: |
C6H3ClF2O2S |
| F.W.: |
212.6 |
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Purity: |
99％ |
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Unit: |
g |
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Category: |
Reference Standard |
| Reference: |
Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013); Rouffet, M., et al.: J. Am. Chem. Soc., 132, 8232 (2010) |
| Application: |
2,6-Difluorobenzenesulfonyl chloride is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,6-Difluorobenzenesulfonyl chloride is also a potential inhibitor of zinc proteases. |
| Category: |
Aromatics, Sulfur and Selenium Compounds |
