Dabrafenib Intermedate B |
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| Synonyms: 3-Bromo-2-fluorobenzoic Acid;2-Fluoro-3-bromobenzoic Acid; 3-Bromo-2-fluorobenzenecarboxylic Acid | |
| Cat. No.: D01003 | CAS No.: 161957-56-8 |
| MDL.: | Formula: C7H4BrFO2 |
| F.W.219.01 | Purity: 99％ |
| Storage: | |
| Size/Unit | Price | Qty | Availability | Price Total |
|---|---|---|---|---|
| 1g | $90.00 | Enter qty and click checkbox |
 
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$90.00 |
| Catalog Number： | D01003 | CAS No.: | 161957-56-8 | |
| MDL: | Formula: | C7H4BrFO2 | ||
| F.W.: | 219.01 | Purity: | 99％ | |
| Package: | Unit: | g | ||
| Appearance: | M.P.: | |||
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| Optical Rotation: | Refractive Index: | |||
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| Storage: | Category: | Reference Standard | ||
| Reference: | Brose, M., et al.: Cancer Res., 62, 6997 (2002); Crosignani, S., et al.: J. Med. Chem., 54, 7299 (2011); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013) | |||
| Application: | 3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis). | |||
| Category: | Aromatics | |||