| Catalog Number： |
D01002 |
|
CAS No.: |
630-22-8 |
| MDL: |
|
|
Formula: |
C5H11NS |
| F.W.: |
117.21 |
|
Purity: |
99％ |
| Package: |
|
|
Unit: |
g |
| Appearance: |
White Solid |
|
M.P.: |
114-116ºC |
| B.P.: |
|
|
Density: |
|
| Optical Rotation: |
|
|
Refractive Index: |
|
| Solubility: |
Chloroform, Ethyl Acetate |
|
Stability: |
|
| Storage: |
Refrigerator |
|
Category: |
Reference Standard |
| Reference: |
Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013); |
| Application: |
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents). |
| Category: |
Amines, Sulfur and Selenium Compounds |
