Catalog Number: |
D01002 |
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CAS No.: |
630-22-8 |
MDL: |
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Formula: |
C5H11NS |
F.W.: |
117.21 |
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Purity: |
99% |
Package: |
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Unit: |
g |
Appearance: |
White Solid |
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M.P.: |
114-116ºC |
B.P.: |
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Density: |
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Optical Rotation: |
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Refractive Index: |
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Solubility: |
Chloroform, Ethyl Acetate |
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Stability: |
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Storage: |
Refrigerator |
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Category: |
Reference Standard |
Reference: |
Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013); |
Application: |
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents). |
Category: |
Amines, Sulfur and Selenium Compounds |