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Dabrafenib Intermedate A

Synonyms: 2,2-Dimethylthiopropionamide;2,2-Dimethylpropanethioamide; NSC 381432; Neopentanethioamide; Thiopivalamide
Cat. No.: D01002 CAS No.: 630-22-8
MDL.: Formula: C5H11NS
F.W.117.21 Purity: 99%
Storage: Refrigerator
 
Size/Unit Price Qty Availability Price Total
1g $75.00 Enter qty and click checkbox $75.00
Catalog Number: D01002   CAS No.: 630-22-8
MDL: Formula: C5H11NS
F.W.: 117.21 Purity: 99%
Package: Unit: g
Appearance: White Solid M.P.: 114-116ºC
B.P.: Density:
Optical Rotation: Refractive Index:
Solubility: Chloroform, Ethyl Acetate Stability:
Storage: Refrigerator Category: Reference Standard
Reference: Carter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013);
Application: 2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
Category: Amines, Sulfur and Selenium Compounds