| Catalog Number： |
D01000 |
|
CAS No.: |
1195765-45-7 |
| MDL: |
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Formula: |
C23H20F3N5O2S2 |
| F.W.: |
519.57 |
|
Purity: |
99％ |
| Package: |
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Unit: |
mg |
| Appearance: |
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M.P.: |
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| B.P.: |
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Density: |
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| Optical Rotation: |
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Refractive Index: |
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| Solubility: |
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
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Stability: |
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| Storage: |
Amber Vial, -20°C Freezer, Under inert atmosphere |
|
Category: |
Reference Standard |
| Reference: |
Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013) |
| Application: |
Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma. |
| Category: |
Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |
