| Catalog Number： |
I00001 |
|
CAS No.: |
872511-34-7 |
| MDL: |
|
|
Formula: |
C26H31Cl2N7O3 |
| F.W.: |
560.49 |
|
Purity: |
99％ |
| Package: |
|
|
Unit: |
mg |
| Appearance: |
|
|
M.P.: |
|
| B.P.: |
|
|
Density: |
|
| Optical Rotation: |
|
|
Refractive Index: |
|
| Solubility: |
In DMSO, water with 1 eq. of acid |
|
Stability: |
|
| Storage: |
Store at 0°C (short term), -20°C (long term) |
|
Category: |
Reference Standard |
| Reference: |
Vito Guagnano, et al, Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase, J. Med. Chem., 2011, 54 (20), pp 7066–7083 |
| Application: |
NVP-BGJ398 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.9, 1.4, 1.0 and 60 nM for FGFR1, 2, 3 and 4, respectively. |
| Category: |
|
