| Catalog Number： |
C99501 |
|
CAS No.: |
1022958-60-6 |
| MDL: |
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Formula: |
C28H35ClN6O3 |
| F.W.: |
539.07 |
|
Purity: |
99％ |
| Package: |
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Unit: |
mg |
| Appearance: |
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M.P.: |
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| B.P.: |
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Density: |
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| Optical Rotation: |
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Refractive Index: |
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| Solubility: |
Soluble in DMSO |
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Stability: |
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| Storage: |
Store at 0°C (short term), -20°C (long term) |
|
Category: |
Reference Standard |
| Reference: |
M. Cheng, et al., CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers. Mol Cancer Ther. 2012 Mar;11(3):670-9; M. J. Jacobs, et al, Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor, WO2013134353 A1;Gingrich, D. et al.: J. Med. Chem., 55, 4580 (2012); |
| Application: |
CEP-28122 is a highly potent, selective and orally active ALK inhibitor (Ezymatic IC50: 1.9 nM (ref 1), 3 nM (ref 2), Cellular IC50: 30 nM (ref 2), Cellular IC50 in 75% murine: 300 nM (ref 2)), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK-positive human cancer cells and tumor xenograft models in mice;CEP-28122 is used as an orally efficacious inhibitor of (ALK), analplastic lymphoma kinase, in the treatment of cancer.. |
| Category: |
Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, |
