| Catalog Number： |
G00001 |
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CAS No.: |
1391712-60-9 |
| MDL: |
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Formula: |
C30H38ClN7O3·1.3 HCl |
| F.W.: |
627.5 |
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Purity: |
99％ |
| Package: |
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Unit: |
mg |
| Appearance: |
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M.P.: |
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| B.P.: |
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Density: |
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| Optical Rotation: |
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Refractive Index: |
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| Solubility: |
Soluble in DMSO; Water with 2.0 eq. of HCl |
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Stability: |
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| Storage: |
Store at 0°C (short term), -20°C (long term) |
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Category: |
Reference Standard |
| Reference: |
M. J. Jacobs, et al, Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor, WO2013134353 A1 |
| Application: |
CEP-37440 is a highly potent, selective and orally active inhibitor of ALK (Ezymatic IC50: 3.5 nM , Cellular IC50: 40 nM , Cellular IC50 in 75% human plasma: 120 nM) and FAK (Ezymatic IC50: 2.3 nM , Cellular IC50: 88 nM ), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK /FAK mediated human cancer cells and tumor xenograft models in mice. It is currently in clinical trials. |
| Category: |
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